Continuous Anticancer drug discovery and development is difficult to find a complete cure for cancer. Due to the drug resistance developed by tumour cells for existing treatments, this is becoming a mandatory approach to fight the disease.
Scientific investigations on inhibitors of checkpoint CHK1 can be another milestone for anticancer drug discovery approach. Cancer cells are specifically dependent on molecular chaperones and related proteins that regulate homeostasis. These are promising targets for new anticancer therapies. Deregulated apoptosis is hallmark of cancer and Bcl-2 family of proteins are pivotal to mediating the pathway of this process. Inhibiting their process can be a significant way for developing new anticancer drugs. Many plant sources are known to be important sources of novel anti-cancer properties.